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Movement of cell, which is actualized by actin-cytoskeleton, is one of the most essential phenomena to sustain life itself. Through bacte-ria to animals and plants, cell motility play an important role on each step of cellular events such as cell shape maintenance and cell migra-tion (1), host-pathogen interaction and pathogen invasion (1), and cell polarity (2,3). Furthermore, the actin cytoskeleton significantly contributes to the cellular pathogenesis in a number of disease states such as cholangiocyte, glomerulosclerosis and Wiskott-Aldrich syndrome (4-7). Consequently, the cell motility comes to the center of research mainly because it is the final consequence of real action of cells responding to various extracellular signals. Therefore, an elucidation of the fundamentals of cell motility is essential to the understanding of the cell functions. Cells move by itself in a motor-independent manner by using actin-cytoskeleton. In the center of actin-cytoskeleton dynamics, monomeric actin (G-actin), one of the most abundant and well-conserved molecule between species, plays a central role equilibrating with its filamentous form (F-actin) to a specific cellular signals in cells. Thus, knowledge of the precise molecular mechanism of actin-cytoskeleton dynamics is indispensable to the understanding of its relationship between cellular functions, for example, cell motility and diseases
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